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Year : 2013  |  Volume : 2  |  Issue : 1  |  Page : 37-42

Incidence of Von Willebrand Disease Among Patients presenting with Various Bleeding Tendency to Out-Patient Clinic of the National Center of Hematology

the national center of hematology/Almustansiriya university

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Background : Von Willebrand disease is frequent hereditary bleeding disorders with an incidence of about 1% in asymptomatic people. Previous Studies available around the Middle East displayed a prevalence ranged from 3 % to 34 % of Von Willebrand disease within the hereditary bleeding disorders. People with mucocutaneous bleeding represent a major subtype of hematologic clinical presentations but simultaneously present a substantial diagnostic challenge. On the other hand, bleeding symptoms are frequent in the general population, but their clinical relevance may be difficult to assess The aim of this study was to estimate the incidence of Von Willebrand disease in patients presenting with various bleeding tendencies to out-patient clinic of the national center of hematology Methods: A total of 146 sequential patients referred to the national center of hematology between January 2011 and April 2012 were investigated .Tests performed for the diagnosis of Von Willebrand disease included complete blood count and blood film including platelet count, bleeding time, prothrombin time, activated partial thromboplastin time, Factor VIII:C assay, and von Willebrand Factor Antigen assay. Results : Amongst 146 patients, 29 (19.8%) had Von Willebrand disease. Patients' age ranged from 1 year to 65 years, with 35 males and 111 females. Menorrhagia was the most common presentation. Amongst vWD patients, there were 7 male and 22 female. Positive family history in patients with VWD was found in 21 out of 29 patients (72.4 %) while positive family history in bleeding tendency other than VWD was found in 47 patients (40%). Statistical significant differences were found in prothrombin time, activated partial thromboplastin time, Factor VIII: C assay, and von Willebrand Factor Antigen assay between the studied groups. Conclusions: Von Willebrand disease still among the most common cause of inherited bleeding tendency in patients presented with mucocutaneous or menorrhagia, yet many cases of vWD remain undiagnosed due to wide range of clinical presentations and lack in lab diagnosis.

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