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Year : 2015  |  Volume : 4  |  Issue : 1  |  Page : 119-125

Assessment of serum ferritin levels in thalassemia and non-thalassemia patients presented with anemia

1 Forensic DNA Research and Training Center, AL- Nahrain University
2 Ibn Al- Baladi Hospital / Baghdad Health Office /Al Rusafa/ Ministry of Health

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Source of Support: None, Conflict of Interest: None

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Background: Thalassemia is an autosomal genetic disease leading to anemia and remains one of the major health problems in Southeast Asia and other parts of the world. Almost 100,000 patients with major thalassemia need regular transfusion. Human hemoglobin (Hb) is the molecule that carries and transports oxygen all through the body. Ferritin is the principal iron storage protein, found in the liver, spleen, bone marrow, and to a small extent in the blood. Objectives: The aim of this study was to assess serum ferritin levels in B-thalassemia patients, and to compare it with non-thalassemic anemia and healthy control. Materials and methods : A prospective cross sectional study conducted at Thalassemia Center in Ibn Al- Baladi Hospital for Children and Women during the period from1st February to 30th May 2014 during their attendance to out-patient clinic. A total .number of 101 patients complaining of anemia (51 patients with thalassemia, 50 with non-thalassemia) in addition to 50 healthy subjects considered as control. All patients were tested for Serum ferritin levels and all results were obtained through automated quantitative test for use Vidas machine Results : The mean serum ferritin levels in cases of thalassemia was 9542 ± 782 ng/ml while serum ferritin levels in control sample was 138 ± 323 ng/ml in male and 28 ± 108 ng/ml in female . in patients with non-thalassemia anemia, the levels of serum ferritin was 1 ± 80 ng/ml. Age of all patients in this study ranged from 3day-9year .the age of thalassemia patients ranged from 1-6 year and p-value was(0.23) while the age of patients with non-thalassemia anemia was 1-5 year and p-value was (0.11). Conclusion: This study confirm that serum ferritin is high in patients wih thalassemia than non thalassemia.

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