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Year : 2016  |  Volume : 5  |  Issue : 2  |  Page : 187-191

Pure red cell aplasia in chronic lymphocytic leukemia: Case report and review of literature

1 Department of Clinical Hematology, Merjan Teaching Hospital, Hilla, Babylon, Iraq
2 Department of Hematopathology, Baghdad Teaching Hospital, Babylon University College of Medicine, Babylon, Iraq

Correspondence Address:
Hassanain H Al-Charrakh
Merjan Teaching Hospital, Hilla, Babylon
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2072-8069.198131

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Despite being immune deficient, chronic lymphocytic leukemia (CLL) patients have an increased incidence of autoimmune cytopenias secondary to autoantibody formation. These are: warm autoimmune hemolytic anemia; idiopathic thrombocytopenia; pure red cell aplasia (PRCA), and In this case report, we describe a patient with CLL who developed severe anemia requiring frequent red cell transfusion after the third cycle of chemotherapy. Blood film showed no evidence of hemolysis and absolute reticulocytopenia. Bone marrow showed erythroid hypoplasia and residual interstitial infiltrate of CLL. The diagnosis of CLL-induced PRCA was made, and the patient showed a prompt and dramatic response to treatment with cyclosporine.

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