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 Table of Contents  
ORIGINAL ARTICLE
Year : 2022  |  Volume : 11  |  Issue : 1  |  Page : 38-44

Health-related quality of life among hemophilic adult patients from Iraq/Duhok


1 Azadi Teaching Hospital, Duhok Directorate of Health, Duhok, Iraq
2 Department of Pathology, College of Medicine, University of Duhok, Duhok, Iraq

Date of Submission26-Dec-2021
Date of Acceptance15-Jan-2022
Date of Web Publication09-Jun-2022

Correspondence Address:
Dr. Hozan Jarjees Abdulrahman
Azadi Teaching Hospital, Duhok Directorate of Health, Duhok
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijh.ijh_48_21

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  Abstract 


BACKGROUND: A case − control study was carried out to evaluate the health-related quality of life of adult hemophilic patients.
MATERIALS AND METHODS: All registered hemophilia cases (40 cases, 36 hemophilia A and 4 hemophilia B) at Jin Blood Center in Duhok/Iraq as well as 40 normal age-matched healthy male individuals were assessed using the medical outcome study “MOS-SF (version 1.0)” so called RAND 36-item health survey 1.0, that assess eight health status scales namely: physical functioning, role-limitation due to physical health, role-limitation due to emotional problem, vitality (energy/fatigue), emotion well-being, bodily pain, social functioning, and general health.
RESULTS: The study included eight patients with mild hemophilia, 18 patients with moderate hemophilia, and 14 patients with severe hemophilia, with ages range from 17 to 57 years with the mean age of 27.85 years (±1.65). Patients with severe hemophilia were diagnosed significantly at earlier age compared with those with mild hemophilia. The study confirmed significantly reduced quality of life (QoL) in all 8 assessed areas particularly among severely affected patients with a P value consistently <0.001. The most affected domain was the role limitation due to physical health at 22.56% and emotional well-being at 32.71. All assessed areas were significantly preserved if early prophylaxis initiated. Other factors that were linked significantly with diminished QoL include the development of hemophilic arthropathy. The factors that did not show significant impact included positive viral hepatitis markers, presence of life-threatening bleedings, socioeconomic state, and positive family history.
CONCLUSION: Hemophilic patient displayed significant impairment of QoL, particularly after the development of arthropathy and restriction of physical activity and can be preserved with early prophylactic therapy.

Keywords: Hemophilia, prophylaxis, quality of life, RAND 36


How to cite this article:
Abdulrahman HJ, Eissa AA. Health-related quality of life among hemophilic adult patients from Iraq/Duhok. Iraqi J Hematol 2022;11:38-44

How to cite this URL:
Abdulrahman HJ, Eissa AA. Health-related quality of life among hemophilic adult patients from Iraq/Duhok. Iraqi J Hematol [serial online] 2022 [cited 2022 Nov 29];11:38-44. Available from: https://www.ijhonline.org/text.asp?2022/11/1/38/346951




  Introduction Top


Hemophilia is a sex-linked inherited genetic disorder with impaired hemostasis mostly affecting males, and results from total or partial lack of clotting factors VIII or IX.[1] It usually manifests clinically as increased bleeding tendency either spontaneously or following trauma and surgical interference. Bleeding in contrast to platelets disorders usually involves joints and muscles, which in most cases lead to chronic long-standing pain, discomforts, reduction in the range of joint movement, and ultimately progression into chronic arthritis.[2] Their consequence on joints and muscles results in disabilities and an impairment of health-related quality of life (HRQoL).[3],[4]

HRQoL, as defined by the WHO, is the clear value of life features on the individual's awareness of their own location in life, in the background of the philosophy and worth systems in which they live, and in relation to their goals, outlooks, values and apprehensions.[5] It is a multidimensional construct concerned with the mental, emotional, social, behavioral, and physical components of well-being and function as apparent by the patients and/or observers. It is not only affected by illness and its management but also by individual features such as handling, personal insight about the primary chief causes of events in his or her life, living conditions, and socioeconomic status.[6] Studies on HRQoL are built on the progressively noticeable requirement for health maintenance that are not to be restricted in averting decease, but to emphasis instead on the benefits of healthiness.[7]

In recent years, there has been an increasing interest in assessing the consequence of hemophilia on quality of life (QoL) with a cumulative number of printed works on this topic. The assessment of HRQoL is necessary for a complete perception of the impact of a long-lasting disease on persons and to assess the influence of various management approaches.[8]

There are different studies using the disease-specific and generic HRQoL questionnaires, in particular the Medical Outcomes Study SF36, which is a famous example of a standardized QoL questionnaire that assess eight areas of life to evaluate the QoL. The outcomes of the SF36 are often compared with standard population statistics to assess the influence of a precise health disorder.[9] The current study aimed to evaluate HRQoL among adult patients with hemophilia at Duhok governorate using the SF36 questionnaire.


  Materials and Methods Top


A case − control study carried out on all adult hemophilic patients (40 male patients, older than 16 years of age, 36 patients with hemophilia A and 4 patients with hemophilia B) registered at Jin hematology and oncology center in Duhok city/Iraq in the period between December 2020 and May 2021. It also includes 40 healthy males with comparable ages as a control group. All included patients were diagnosed with hemophilia according to the World Federation of Hemophilia guidelines (3rd edition).[10] The study was approved by the Ethical Committees of both general directorate health of Duhok and Iraqi board for medical specialties commission. Patients were acknowledged and a formal agreement was obtained from all participants at the start of the study.

Data obtained from all patients including

Residence, age of patients at the time of the study, age at first bleeding episode and diagnosis, nature and severity of hemophilia, past history of inhibitors, markers for transmitted viral infections, number of bleeding events requiring treatment in the past 3 months, life-threatening bleeding events throughout the patients' life, sites, and presence of chronic pain (pain of >3 months duration). Later on, examination done looking for the joints deformity, swelling, muscle atrophy, and limitation of movement.

Information regarding treatment included type o therapy (episodic or on demand), admission history, product used for treatment, recombinant factor VIII or cryoprecipitate. In addition to the previous information, patients further asked about education, job of the patient, marital status, and socioeconomic status.

All enrolled individuals were assessed using a reliable Arabic version of medical outcome study “MOS-SF (version 1.0)” so called RAND 36-item health survey.[11],[12] This was administrated either by self-reporting or by an interview (if illiterate or unable to complete by self-administration), both Kurdish and Arabic-translated version of this questionnaire were used. This survey includes eight health status scales, namely physical functioning, role-limitation due to physical health, role-limitation due to emotional problem, vitality (energy/fatigue), emotion well-being, bodily pain, social functioning, and general health.[11] After the collection of data, scoring calculated using the scores system of the SF-36-rand questionnaire. The scores range from 0 to 100, with higher scores indicating a higher QoL, better functioning, less limitation or less pain. In step 2, the means (± standard deviations [SD]) were calculated for each the 8 domains.

Statistical and data analyses were performed using the Statistical Package for the Social Sciences software, version 22 (SPSS Inc., Chicago, IL, USA). The results were reported as mean values ± SD. The t-test and Pearson correlation were used as appropriate, whereas ANOVA test was used to make the comparisons between the scores among various sets of patients relating the number of complications, P < 0.05 was considered statistically significant.


  Results Top


The study included all 40 male patients with hemophilia registered at Jin center and 40 age matched apparently healthy male controls. The patients' ages range from 17 to 57 years with a mean age of 27.85 years (±1.65).

From all patients, majority (18 patients (45.0%)) had moderate hemophilia followed by 14 patients (35.0%) with severe hemophilia and 4 patients (20%) with mild hemophilia. The mean age of diagnosis was 21.45 ± 6.59 months. Patients with severe hemophilia were diagnosed at mean age (12.07 ± 4.06 months), compared with those with moderate (13.02 ± 4.06 months) and mild hemophilia (56.87 ± 29.02), P = 0.87, <0.001, respectively.

Patients with severe hemophilia as shown in [Table 1], tend to have nonsignificant higher rate of bleeding in the last 4 weeks (1.21 ± 0.26) compared to those with moderate (1.05 ± 0.20) and mild hemophilia (0.87 ± 0.89) with a P = 0.82 and 0.56, respectively, though the bleeding tend to be more severe in patient with severe to moderate (mainly joint bleeding) than patients with mild hemophilia (mucocutaneous bleedings). Patients with severe to moderate hemophilia develop significantly target joint at higher rate than mild hemophilic patients with a P = 0.0432. None of the enrolled patients had developed inhibitors.
Table 1: Main clinical characteristics of all patients

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By using the SF36 form scoring table and calculating the scores of the forty adult patients enrolled in the study, the overall mean HRQoL score was 41.9 ± 23.81, which was significantly lower than that of the enrolled matched healthy controls (84.45 ± 9.23) (P < 0.001). The most affected domain of the eight SF36 domains was the role limitation due to physical health at 22.56% and emotional well-being at 32.71. All of the eight domains of the SF36 form were significantly lower in adult patients as compared to the healthy controls [Table 2].
Table 2: Health-related quality of life (short form 36) score (%) comparison between adult patients with hemophilia and healthy controls

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Comparing different severities, two domains including emotional well-being and social function showed significant difference in score among patient with severe hemophilia to that with mild hemophilia, with a P = 0.021 and 0.029, respectively [Table 3]. Despite this, no significant difference in HRQoL in all of the eight domains found between mild and moderate and also moderate with severe hemophilic patients.
Table 3: Health-related quality of life of adult hemophilic patient short form 36 score (%) in relation to the severity of factor deficiency

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No significant difference in HRQoL in all the eight domains in relation to the socioeconomic status of the hemophilic patients, while significant lower scores of hemophilic HRQoL in four domains (energy and fatigue, social functioning, general health, and emotional well-being) in patients having more than one bleed per month than those having no bleeds. Patients having chronic pain have significantly lower scores in two domains (role of physical function and general health), P < 0.05, [Table 4].
Table 4: Health-related quality of life of adult hemophilic patients and its relation to some clinical and socioeconomic parameters

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Another significant difference seen in one domain only (role of emotional) in relation to family history as patients with positive family history had significantly lower score in comparison to those with negative family history. Furthermore, significant lower result in patients having episodic treatment in all eight domains of HRQoL in comparison to patients on prophylaxis [Table 4].

Although the overall mean HRQoL was higher in hemophilic patients having life-threatening bleeding and viral hepatitis, none of them were significantly different in all of the eight domains. While there was significant difference in all of the eight domains of HRQoL in regards of joint impairment having P < 0.05 [Table 5].
Table 5: Health-related quality of life of adult hemophilic patients and its relation to some common complication

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  Discussion Top


Hemophilia is worldwide genetic disease affecting one in every 10000 new-born and manifests as increased bleeding tendency, particularly into joints and muscles.[13] It is a chronic disease that can have a burden on the QoL of affected individuals and despite the widespread epidemiology of the disease, limited data are available particularly on the HQoL of affected individuals in the Middle East, thus the current study initiated to tackle such paucity of data in the Iraq/Duhok.

Numerous studies established previously connect several factors to the clinical behavior of the disease including severity of the disease as mild cases demonstrated lower impact of the disease on the emotional and social parameters of HRQoL of enrolled patients.[14] Fortunately, one factor documented to be negatively linked with the QoL in hemophilic patients and that have psychosocial effect on their families and caregivers, inhibitor development was not detected among our patients.[15] This, in contrast to the global data on inhibitor development with accumulative incidence of FVIII inhibitors reaching to approximately 25% (0%–52%) in patients with severe hemophilia A, and previous data from Iraq with an incidence of 11.6%–22.2%,[16],[17],[18],[19] may reflect the targeted studied population (adults) with lower incidence of inhibitors, genetic background, racial factors, or small number of studied patients.[20],[21]

All parameters of HRQoL particularly of role of physical and emotional well-being were lower than that of normal individuals and lower than that reported from hemophilic patients from European countries, but comparable to those reported from Brazilian hemophilic patients.[22],[23] With the early diagnosis, education of the families' members particularly of those with new mutation “as 7/40 (17.5%) patients do not have family history,” and early initiation of prophylaxis decreases the episodes of bleeding and hence the establishment of hemophilic joint diseases, possibly severe discomfort, pain and incapacity as a result, and enhances the patients' HRQoL. Our findings of relatively small number of patients (2 cases from 40), were comparable to that reported from a study conducted from Italy on elderly patients aged > 65 years with severe hemophilia, the vast majority of patients who failed to receive prophylactic therapy, showed severe reductions in HRQoL, with a negative impact on the emotional and social comfort as compared to healthy controls and also inferior orthopedic standing which negatively associated with HRQoL.[24]

The major complication revealed to have impact on all eight areas of QoL in the present study was the development of the hemophilic arthropathy as in patients with hemophilia, the main problem is the limitations on physical activities, fear of hemorrhage that could be serious and life-threatening, the establishment of arthropathy, the necessity for orthopedic interferences, and currently less likely complication, infections transmitted by blood and blood products.[25]

Limitation

Small numbers of patients included as all registered cases enrolled. Furthermore, limited number of patients on prophylactic therapy in comparison to those with on demand therapy due to unavailability of the factor VIII for prophylactic therapy.


  Conclusion Top


Patients of hemophilia have impaired QoL, particularly after the development of arthropathy and restriction of physical activity and can be improved with prophylactic therapy.

Ethical approval

The study was approved by the ethical committee of both general directorate health of Duhok and Iraqi board for medical specialties commission. Verbal informed consent was obtained after the study was explained to the patients.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Gater A, Thomson TA, Strandberg-Larsen M. Haemophilia B: Impact on patients and economic burden of disease. Thromb Haemost 2011;106:398-404.  Back to cited text no. 1
    
2.
Rasheed B, Eissa A. Impact of IL-1Ra gene polymorphism on the etiology and fate of disease in children with immune thrombocytopenic purpura. J Immunol Res 2021;7505673:5.  Back to cited text no. 2
    
3.
Dolan G, Hermans C, Klamroth R, Madhok R, Schutgens RE, Spengler U. Challenges and controversies in haemophilia care in adulthood. Haemophilia 2009;15 Suppl 1:20-7.  Back to cited text no. 3
    
4.
Barr RD, Saleh M, Furlong W, Horsman J, Sek J, Pai M, et al. Health status and health-related quality of life associated with hemophilia. Am J Hematol 2002;71:152-60.  Back to cited text no. 4
    
5.
Development of the World Health Organization WHOQOL-BREF quality of life assessment. The WHOQOL Group. Psychol Med 1998;28:551-8.  Back to cited text no. 5
    
6.
Remor E, Young NL, Von Mackensen S, Lopatina EG. Disease-specific quality-of-life measurement tools for haemophilia patients. Haemophilia 2004;10 Suppl 4:30-4.  Back to cited text no. 6
    
7.
Bungay KM, Gouveia WA. Assessment of health-related quality of life by health care profissionals. In: Knowlton CH, Penna RP, editor. Pharmaceutical Care. New York: Chapman & Hall; 1996. p. 114-30.  Back to cited text no. 7
    
8.
Haverman L, Grootenhuis MA, van den Berg JM, van Veenendaal M, Dolman KM, Swart JF, et al. Predictors of health-related quality of life in children and adolescents with juvenile idiopathic arthritis: Results from a Web-based survey. Arthritis Care Res (Hoboken) 2012;64:694-703.  Back to cited text no. 8
    
9.
Ware JE. Measuring patients' views: The optimum outcome measure. BMJ 1993;306:1429-30.  Back to cited text no. 9
    
10.
Srivastava A, Santagostino E, Dougall A, Kitchen S, Sutherland M, Pipe SW, et al. WFH guidelines for the management of hemophilia, 3rd edition. Haemophilia 2020;26 Suppl 6:1-158.  Back to cited text no. 10
    
11.
Hays RD, Morales LS. The RAND-36 measure of health-related quality of life. Ann Med 2001;33:350-7.  Back to cited text no. 11
    
12.
Coons SJ, Alabdulmohsin SA, Draugalis JR, Hays RD. Reliability of an Arabic version of the RAND-36 health survey and its equivalence to the US-English version. Med Care 1998;36:428-32.  Back to cited text no. 12
    
13.
Mackensen S, Gringeri A. Quality of life in hemophilia. In: Preedy VR, Watson RR, editors. Handbook of Disease Burdens and Quality of Life Measures. New York, NY: Springer; 2010. Available from: https://doi.org/10.1007/978 0 387 78665 0_112.  Back to cited text no. 13
    
14.
Solovieva S. Clinical severity of disease, functional disability and health-related quality of life. Three-year follow-up study of 150 Finnish patients with coagulation disorders. Haemophilia 2001;7:53-63.  Back to cited text no. 14
    
15.
Miners AH, Sabin CA, Tolley KH, Jenkinson C, Kind P, Lee CA. Assessing health related quality-of-life in individuals with haemophilia. Haemophilia 1999;5:378-85.  Back to cited text no. 15
    
16.
Lorenzo JI, López A, Altisent C, Aznar JA. Incidence of factor VIII inhibitors in severe haemophilia: The importance of patient age. Br J Haematol 2001;113:600-3.  Back to cited text no. 16
    
17.
Hay C, Palmer B, Chalmers E, Liesner R, Maclean R, Rangarajan S, et al. Incidence of factor VIII inhibitors throughout life in severe hemophilia A in the United Kingdom. Blood 2011;117:6367-70.  Back to cited text no. 17
    
18.
Taresh AK, Hassan MK. Inhibitors among patients with hemophilia in Basra, Iraq – A single center experience. Niger J Clin Pract 2019;22:416-21.  Back to cited text no. 18
[PUBMED]  [Full text]  
19.
Kadhim K, Al-Lami F, Baldawi KH. Epidemiological Profile of Hemophilia in Baghdad-Iraq. INQUIRY: The Journal of Health Care Organization, Provision, and Financing. January 2019. doi:10.1177/0046958019845280.  Back to cited text no. 19
    
20.
Witmer C, Young G. Factor VIII inhibitors in hemophilia A: Rationale and latest evidence. Ther Adv Hematol 2013;4:59-72.  Back to cited text no. 20
    
21.
Eissa A. The effect of vitamin K epoxide reductase complex and cytochrome P450 gene polymorphisms on warfarin dose among Kurdish patients in Duhok-Iraq. Duhok Med J 2016;10:77-84.  Back to cited text no. 21
    
22.
Ucero-Lozano R, López-Pina J, Ortiz-Pérez A, Rubén Cuesta-Barriuso R. Quality of life and its predictors among adult patients with haemophilic arthropathy. An observational study. BMC Musculoskelet Disord 2021;22:448.  Back to cited text no. 22
    
23.
Ferreira AA, Leite IC, Bustamante-Teixeira MT, Corrêa CS, da Cruz DT, Rodrigues Dde O, et al. Health-related quality of life in hemophilia: Results of the hemophilia-specific quality of life index (Haem-a-Qol) at a Brazilian blood center. Rev Bras Hematol Hemoter 2013;35:314-8.  Back to cited text no. 23
    
24.
von Mackensen S, Gringeri A, Siboni SM, Mannucci PM; Italian Association Of Haemophilia Centres (AICE). Health-related quality of life and psychological well-being in elderly patients with haemophilia. Haemophilia 2012;18:345-52.  Back to cited text no. 24
    
25.
Beeton K, Neal D, Lee C. An exploration of health-related quality of life in adults with haemophilia – A qualitative perspective. Haemophilia 2005;11:123-32.  Back to cited text no. 25
    



 
 
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  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5]



 

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