Year : 2022 | Volume
: 11 | Issue : 2 | Page : 103--109
Microalbuminuria among children and adolescents with sickle cell disease
Meaad Kadhum Hassan1, Lamia Mustafa Al-Naama2, Sammer Muayed Jawad3
1 Department of Pediatrics, College of Medicine, University of Basrah, Basrah, Iraq
2 Department of Biochemistry, College of Medicine, University of Basrah, Basrah, Iraq
3 Department of Pediatrics, Al-Sader Teaching Hospital, Misan, Iraq
BACKGROUND: Sickle cell nephropathy, a heterogeneous group of renal abnormalities resulting from complex interactions of sickle cell disease (SCD)-related factors and non-SCD phenotype characteristics, is associated with an increased risk for morbidity and mortality.
AIMS: The aims of this study were to determine the frequency of microalbuminuria (MA) among pediatric patients with SCD and to determine risk factors for MA among those patients.
SUBJECTS AND METHODS: A case–control study was carried out on 120 patients with SCD, 2–18 years old, registered at Basrah Center for Hereditary Blood Diseases, and 132 age- and sex-matched healthy children were included as a control group. Investigations included complete blood panel, blood urea, serum creatinine (Cr), urinalysis, and urinary albumin-to-Cr ratio (ACR). Logistic regression analysis was used to assess the predictors of MA.
RESULTS: Among SCD patients, 39 (32.5%) had MA compared to 6 (4.5%) in the control group. The mean levels of blood urea, serum Cr, and ACR were significantly higher, and the urine-specific gravity was significantly lower in SCD patients than in the control group (P < 0.05). Logistic regression analysis revealed that frequent painful crisis (odds ratio [OR]: 12.146, confidence interval [CI]: 3.439–42.952), high serum ferritin (OR: 8.146, CI: 1.802–36.827), deferoxamine therapy (OR: 23.423, CI: 3.961–60.509), and female sex (OR: 4.590, CI: 1.225–17.202) are independent risk factors for MA (P < 0.05).
CONCLUSION: The frequency of MA was high among our pediatric SCD patients. Risk factors for MA include female sex, nutritional factors, painful episodes, and iron overload. This is important for planning for future follow-up and management of this common disease in our locality.
Prof. Meaad Kadhum Hassan
Department of Pediatrics, College of Medicine, University of Basrah, Basrah
|How to cite this article:|
Hassan MK, Al-Naama LM, Jawad SM. Microalbuminuria among children and adolescents with sickle cell disease.Iraqi J Hematol 2022;11:103-109
|How to cite this URL:|
Hassan MK, Al-Naama LM, Jawad SM. Microalbuminuria among children and adolescents with sickle cell disease. Iraqi J Hematol [serial online] 2022 [cited 2023 Mar 22 ];11:103-109
Available from: https://www.ijhonline.org/article.asp?issn=2072-8069;year=2022;volume=11;issue=2;spage=103;epage=109;aulast=Hassan;type=0